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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222
Ashvani K. Singh, Yihong Fan, Corina Balut, Sara Alani, Arlene M. Manelli, Andrew M. Swensen, Ying Jia, Torben R. Neelands, Timothy A. Vortherms, Bo Liu, Xenia B. Searle, Xueqing Wang, Wenqing Gao, Tzyh-Chang Hwang, Hong Y. Ren, Douglas Cyr, Philip R. Kym, Katja Conrath and Chris Tse

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 107-118; DOI: https://doi.org/10.1124/jpet.119.261800
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The Positive Allosteric Modulator of α2/3-Containing GABA_A Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury
Jeffrey M. Witkin, Guanguan Li, Lalit K. Golani, Wenhui Xiong, Jodi L. Smith, Xingjie Ping, Farjana Rashid, Rajwana Jahan, Rok Cerne, James M. Cook and Xiaoming Jin

Journal of Pharmacology and Experimental Therapeutics January 2020, 372 (1) 83-94; DOI: https://doi.org/10.1124/jpet.119.260968
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A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer
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Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 703-712; DOI: https://doi.org/10.1124/jpet.119.261040
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A Novel Phosphodiesterase 1 Inhibitor DSR-141562 Exhibits Efficacies in Animal Models for Positive, Negative, and Cognitive Symptoms Associated with Schizophrenia
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Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 692-702; DOI: https://doi.org/10.1124/jpet.119.260869
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Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase
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Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 652-662; DOI: https://doi.org/10.1124/jpet.119.262188
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The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents
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Utilization of ¹⁸F-Fluorodeoxyglucose–Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo
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Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 583-589; DOI: https://doi.org/10.1124/jpet.119.259135
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Pharmacological Profile of JNJ-64179375: A Novel, Long-Acting Exosite-1 Thrombin Inhibitor
Zheng Huang Devine, Fuyong Du, Qiu Li, Matthew Bunce, Eilyn R. Lacy and Madhu Chintala

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 375-384; DOI: https://doi.org/10.1124/jpet.119.261032
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In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution
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Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 327-338; DOI: https://doi.org/10.1124/jpet.119.258624
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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors
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Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028

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