Abstract
Carinamide has been shown to prolong the sedative effects of thiopental, pentobarbital, and seconal in mice. The observed increase in thiopental sleeping time was proportional to the size of the carinamide dose and appeared to be due to the interference by carinamide with the degradation of thiopental. The rate of degradation of thiopental was inversely proportional to the size of the carinamide dose.
Footnotes
- Received March 27, 1949.
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EFFECT OF CARINAMIDE (4' CARBOXYPHENYLMETHANE SULFONANILIDE) ON THE METABOLISM OF THIOPENTAL IN MICE
