Abstract
1. The general pharmacological properties of a series of acetamidines and propionamidines have been presented.
2. A small minority of the amidines exhibited marked anticholinergic and somewhat less marked antihistaminic activity. The presumed structural requisites to those actions have been discussed.
3. A minority of the amidines comprised a second group that exhibited marked positive inotropic and chronotropic effects upon the perfused heart and the heartlung preparation. The presumed structural requisites to that action have been discussed in detail.
Footnotes
- Received March 23, 1950.
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SOME PHARMACOLOGICAL PROPERTIES OF A SERIES OF ACETAMIDINES AND PROPIONAMIDINES
