Abstract
Of an oral dose of 2 gm. of Myanesin, 28 per cent was excreted in the urine in 24 hours as β-(o-toloxy)-lactic acid; 54 per cent of a 4 gm. dose was similarly eliminated. Elimination of β-(o-toloxy)-lactic acid was complete in 24 hours after the larger dose.
No evidence was found to indicate that appreciable quantities of free Myanesin are excreted in the urine of humans. No significant amounts of the drug are degraded to o-toloxyacetic acid or to o-cresol in man or in rats.
Tissue storage of Myanesin as fatty acid esters is not appreciable.
Footnotes
- Received March 15, 1950.
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METABOLISM OF MYANESIN (3-(O-TOLOXY)-1, 2-PROPANEDIOL)
