Abstract
Methods are described for the determination of acetanilide and its metabolites. The procedure for acetanilide permits estimation of as little as 4 micrograms of the compound, that for aniline as little as 0.25 micrograms, for N-acetyl p-aminophenol and total conjugated p-aminophenol as little as 10 micrograms.
A comparison of the solubility characteristics of the authentic compounds and the apparent compounds extracted from the plasma and urine of subjects receiving acetanilide, indicates that the methods have a high degree of specificity.
Footnotes
- Received May 11, 1948.
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THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES
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