Abstract
1. n-Amyl mercaptan in an intraperitoneal dose of 0.5 ml./kg. was successful in delaying the onset of symptoms, increasing survival time, and reducing mortality when administered to rats simultaneously with the intraperitoneal injection of 2 LD50's of ANTU. When injected prophylactically one hour before ANTU was given, or therapeutically one hour following ANTU administration, the amyl mercaptan was approximately equally effective. Even against highly lethal doses of 5 and of 10 LD50's of ANTU, this compound decreased the mortality and markedly increased survival time.
2. Of other mercaptans tested, tertiary butyl was not quite as effective as the n-amyl; benzyl mercaptan was only slightly effective; and tertiary dodecyl mercaptan produced no beneficial results. Hydrosulphosol, reputed to contain free—SH groups, conferred no protection.
3. Experiments conducted with 2-methylmercaptoethanol, 1,2-bis(2-hydroxy-ethyl-1-thio) ethylene, and bis (2,2'-hydroxyethylmercaptoethyl) sulfide, were all negative. However, thiodiglycol caused a delay in the onset of symptoms, an increase in survival time, and a reduction in mortality when injected intra-peritoneally in doses of 1.5 or 2.0 ml./kg. simultaneously with the injection of 2 LD50's of ANTU.
4. Sodium diethyldithiocarbamate, rutin, sodium salicylate, and 5-iodoacetyl-salicylic acid were totally ineffective against 2 LD50's of ANTU.
Footnotes
- Received April 7, 1948.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|