Abstract
1. Racemic nor-epinephrine is distinctly more pressor than racemic epinephrine.
2. Inhibitory (sympathin I-mimetic) actions of nor-epinephrine are increased by N-alkyl substitution.
3. The structure of the N-alkyl group is an important factor influencing inhibitory potency.
4. Inhibitory effects are not prominent with those hydroxytyramine derivatives that do not contain the alcoholic hydroxyl of nor-epinephrine.
5. The significance of these findings is discussed.
Footnotes
- Received August 25, 1947.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
In this issue
THE PHARMACOLOGY OF COMPOUNDS STRUCTURALLY RELATED TO HYDROXYTYRAMINE
