Abstract
1. Racemic nor-epinephrine is distinctly more pressor than racemic epinephrine.
2. Inhibitory (sympathin I-mimetic) actions of nor-epinephrine are increased by N-alkyl substitution.
3. The structure of the N-alkyl group is an important factor influencing inhibitory potency.
4. Inhibitory effects are not prominent with those hydroxytyramine derivatives that do not contain the alcoholic hydroxyl of nor-epinephrine.
5. The significance of these findings is discussed.
Footnotes
- Received August 25, 1947.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
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