Abstract

The action of a group of aminophenyltetrazole derivatives on the central nervous system has been studied. The presence of a m-aminophenyl, but not the p-aminophenyl group, in either the 1 or 5 position of the tetrazole nucleus produced compounds having primarily depressant actions, depending upon the size of the aliphatic side chain. A schematic diagram of the relation of structure to pharmacologic activity in the 130 compounds of the complete series (1-4 and Group 5) is presented and discussed.