Abstract
Thephorin, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene, one of three closely related pyridindene derivatives studied, proved to be a potent antihistaminic on isolated guinea pig's ileum, in the spray test, against intracardial histamine and against anaphylactic shock. In addition, Thephorin antagonizes spasmogenic effects of acetyl-choline, of Ba-ions and of epinephrine.
Footnotes
- Received October 14, 1947.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
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