Abstract

1. Saturation of the ring of several phenyl compounds to produce cyclohexyl isopropylamines results in compounds which possess prolonged vasopressor effects when given orally.

2. Saturation of the ring results in some diminution of vasopressor effects; the activity of the compounds ranges from one-sixth to two-thirds that of their phenyl analogues when given intravenously. However, these differences were considerably less evident when the drugs were administered orally.

3. The cyclohexyl compounds described here exhibited the unexpected characteristic of being generally much less stimulating upon the central nervous system than their phenyl analogues.