Abstract
1. 5.0 mgm. subcutaneous doses of amidone elevated the pain threshold of non-addicts and former morphine addicts as much as 10-15 mgm. of morphine sulfate.
2. Respiratory rate, pulse rate, rectal temperature and systolic blood pressures were lowered by amidone.
3. 10-30 mgm. doses of amidone subcutaneously had no significant effect on the electrocardiogram.
4. 60-75 mgm. of amidone in divided doses had no significant effect on the blood sugar of former addicts.
5. 30-75 mgm. of amidone always produced sedation in former morphine addicts. The electroencephalographic pattern was sometimes shifted to the slow side after 30-mgm. doses.
6. 30 mgm., or more, of amidone subcutaneously regularly produced euphoria in former morphine addicts; 10-30 mgm. doses intravenously induced intense euphoria. Narcotic drug addicts would abuse amidone if it were freely available.
Footnotes
- Received September 19, 1947.
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