Abstract
1. In cats and monkeys intravenous intocostrin (Squibb) in doses sufficient to produce complete skeletal and respiratory paralysis did not affect the EEG pattern.
2. Intravenous atropine and scopolamine produced a change in the control EEG characterized by a decrease in frequency and an increase in voltage.
3. Intravenous DFP produced a constant EEG effect characterized by an increase in frequency and a decrease in voltage.
4. The action of DFP could be prevented or abolished by the intravenous administration of atropine or scopolamine.
5. Atropine and scopolamine had no prophylactic or therapeutic effect on the convulsions caused by pentamethylenetetrazol (Metrazol), strychnine, or gammexane.
6. These data indicate that atropine prevents or annuls the central actions of ACh.
Footnotes
- Received September 11, 1947.
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