IV. ITS DETOXICATION BY L-CYSTINE, DL-METHIONINE AND CERTAIN OTHER SULFUR CONTAINING COMPOUNDS
Abstract
The sulfur containing amino acids l-cystine and dl-methionine protected young rats against death from inhalation exposures to 1,2-dichloroethane. This was demonstrated when these amino acids supplemented low protein-choline deficient diets and also when they were added to normally constituted rations. Supplements of choline chloride did not give any significant protection. Nine sulfur-free amino acids were found to be nonprotective.
Other sulfur containing compounds were tested for their ability to reduce the toxicity of dichloroethane. The inorganic compounds, Na2SO4, NaCNS, Na2S and Na2S2O3 were ineffective. Cysteic acid, taurine and S-benzyl-l-cysteine did not protect. Protection was obtained with thiourea, thiouracil, 2-thiobarbituric, acid, ββ'-dithiodipropionic acid and l-cysteine hydrochloride. Thiolactic acid was ineffective by mouth but afforded protection when injected intraperitoneally. It is pointed out that all of the protective compounds can furnish sulfhydryl groups.
Footnotes
- Received September 3, 1947.
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