Abstract
1. The bronchodilator effect of five homologues of epinephrine is described.
2. The N-isopropyl homologue, 1-(3', 4'-dihydroxyphenyl)-2-isopropylaminoethanol, was found to be the most effective bronchodilator. The removal of the alcoholic hydroxyl from the beta-carbon, to form 1-(3', 4'-dihydroxyphenyl)-2-aminoethane, resulted in a very great reduction in activity.
3. The branching of the N-alkyl group appears to markedly reduce toxicity.
4. The structural requirements important for effective bronchodilator activity are discussed.
Footnotes
- Received May 1, 1947.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
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