Abstract
1. In rats poisoned with DDT there is an increase in the total metabolic rate.
2. The increased metabolic rate is reflected in an increase in food and water intake and a slight loss in body weight.
3. The oxygen uptake of liver slices from DDT poisoned rats is increased.
4. In advanced DDT poisoning, slices taken from parts of the liver showing gross abnormalities have instead of an increased oxygen uptake a reduction below the control values.
5. The oxygen consumption of sartorius muscles from frogs poisoned with DDT is increased.
6. A significant increase in the respiration of the brain tissue has not been demonstrated.
7. A known metabolite of DDT, di(p-chlorophenyl) acetic acid has been shown not to be responsible for the characteristic actions of DDT.
Footnotes
- Received August 2, 1946.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics
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