Abstract
1. 3,4-Dimethyl-5-sulfanilamido-isoxazole (Nu-445) and its salts possess remarkably good solubility over a wide pH range particularly in the physiologically important range of pH 6.0-8.0.
2. Due to this solubility no kidney damage was produced after prolonged treatment of rats and rabbits with high doses of the compound.
3. The low toxicity of the new compound and its chemotherapeutic activity in vitro and in experimental infections with the most important representatives of gram positive and gram negative pathogenic micro-organisms indicate that that therapeutic potentialities of the compound compare favorably with those of known and clinically useful sulfonamides.
Footnotes
- Received June 16, 1946.
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