Abstract
1. Of the sympathomimetic drugs, the l-mandelate of optically active aromatic amines appears to be more active in raising the blood pressure of pithed dogs than the d-mandelate of the same isomer, as exemplified by l-ephedrine and other previously reported compounds.
2. No difference in pressor action can be detected between the enantiomorphous mandelates of optically inactive amines, such as β-phenylethylamine and tyramine.
3. Neither l- nor d-mandelic acid raises blood pressure.
4. Of the 2-aminoheptane sulfates, the d-isomer having levorotation in water is almost twice as active as the l-isomer, which has a dextrorotation, the dl-isomer being intermediate between the two.
5. Differences in pressor action can be also detected between the enantiomorphous mandelates of d-2-aminoheptane and those of l-2-aminoheptane.
Footnotes
- Received June 8, 1945.
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