Abstract

Circulatory effects of privine HCl on intravenous injection are compared with those of some sympathomimetic amines. In dogs narcotized with pentobarbital, the minimal pressor dose is 1-2 x 10^–5 mM./kg., while a maximum response is usually obtained with 5 x 10^–5 to 10^–4 mM./kg. Above this dose, privine generally causes cardiac irregularities which limit the pressor response. Tachyphylaxis occurs at about this dose. Atropine and cocaine do not appreciably influence the action of privine; 933F reduces but does not reverse the pressor action. Small doses of privine potentiate epinephrine but large doses are adrenolytic. Cheynes-Stokes' respiration often follows injection of large doses.