Abstract
1. The nitrate ester of choline perchlorate is a stable inorganic acid ester which mimics many of the pharmacological responses of acetylcholine.
2. Its depressor potency is approximately one-hall that of acetylcholine. Its depressor effect is obliterated by atropine but not affected by the choline esterase.
3. This ester is approximately ten times as toxic to the rat as is acetylcholine.
4. It is possible that this simple choline ester may find application in therapeutics as a parasympathomimetic drug.
Footnotes
- Received November 3, 1943.
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