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Research ArticleArticle

METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE

J. M. VANDENBELT, CARL PFEIFFER, MARGARET KAISER and MARGARET SIBERT
Journal of Pharmacology and Experimental Therapeutics January 1944, 80 (1) 31-38;
J. M. VANDENBELT
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CARL PFEIFFER
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MARGARET KAISER
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MARGARET SIBERT
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Abstract

The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.

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    • Received August 19, 1943.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 80, Issue 1
1 Jan 1944
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Research ArticleArticle

METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE

J. M. VANDENBELT, CARL PFEIFFER, MARGARET KAISER and MARGARET SIBERT
Journal of Pharmacology and Experimental Therapeutics January 1, 1944, 80 (1) 31-38;

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Research ArticleArticle

METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE

J. M. VANDENBELT, CARL PFEIFFER, MARGARET KAISER and MARGARET SIBERT
Journal of Pharmacology and Experimental Therapeutics January 1, 1944, 80 (1) 31-38;
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