Abstract

The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.