Abstract
1. Some pharmacological actions of adenine-thiomethylpentose, a naturally occurring nucleoside, were studied.
2. Qualitatively its actions are similar to those of other nucleic acid derivatives of this class, i.e., lowering of the blood pressure in rabbits, relaxation of rabbit intestinal strips and contraction of the isolated guinea pig uterus.
3. Quantitatively, it is much weaker than adenosine in increasing blood pressure and relaxing intestinal muscle and approximately equal to adenosine in contracting the guinea pig uterus.
4. Adenosine deaminase does not attack adenine-thiomethylpentose. The significance of this finding in relation to the pharmacological activity is discussed.
Footnotes
- Received July 15, 1943.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.