Abstract
1. Sulfanilamide, sulfapyridine, sulfathiazole, sulfadiazine, or p-aminobenzoic acid, in the form of the sodium salt, when injected into the ventral lymph sac of the spadefoot toad (Scaphiopus holbrookii holbrookii), or the nebulous toad (Bufo valliceps), is partly conjugated as shown in blood and urine. The degree of conjugation as observed in blood is apparently not as great as in the rabbit. In the nebulous toad's blood, the conjugated form of sulfadiazine is unmeasurable.
2. Similarly, conjugation takes place in the tree frog (Hyla cinerea cinerea) with sulfanilamide, sulfapyridine, sulfathiazole, and sulfadiazine.
3. Confirmatory of Marshall's work, sulfanilamide, sulfapyridine, and sulfathiazole are found to be unconjugated in the Leopard frog (Rana pipiens) and the "Jumbo" bullfrog (Rana catesbeiana). Also, sulfadiazine and p-aminobenzoic acid are not conjugated in the former animal.
4. No conjugation takes place in the turtle (Pseudemys elegans) with sulfanilamide, sulfapyridine, sulfadiazine, or p-aminobenzoic acid. There is, however, a slight conjugation with sulfathiazole.
Footnotes
- Received April 16, 1943.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|