Abstract
The action of various drugs on the motility of the fasting stomach in man is recorded.
1. Atropine in small doses has a parasympathomimetic action causing an increase in the frequency and amplitude of the hunger contractions and a slowing of the pulse-rate. This dosage has also a sensitising effect whereby an antiparasympathetic action is obtained from a second small dose. In large doses atropine inhibits the movements of the stomach and quickens the heart-rate.
2. Prostigmin has been shown to have excitor effect on gastric motility. Premedication with atropine does not change this action. If given in large doses, however, the atropine may prevent the stimulating effect of the prostigmin. The effects of atropine are not altered by previous administration of prostigmin.
3. Adrenaline in very small doses occasionally appears to increase gastric motility. Large doses constantly have a sedative action.
4. Calckim has a sedative action on the fasting contractions of the stomach and slows the pulse-rate.
Footnotes
- Received November 16, 1942.
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