Abstract
Methods have been adapted for studying in monkeys the effects of analgesics by their ability to increase the alternating current voltage or the weight on a needle required to produce a sudden respiratory change probably associated with pain.
Insofar as these methods are criteria of pain, acetanilid in a dose of 100 mgm. per kilogram and morphine, in a dose of 10 mgm. per kilogram, have been demonstrated to be effective analgesics in monkeys. With aspect to both time of maximum intensity and duration, analgesia and antipyresis were coincident. In the case of acetaniid, the analgesia is prevented by caffeine but uninfluenced by sodium bicarbonate.
Footnotes
- Received September 30, 1937.
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