Abstract
1. Postlobin-O, administered subcutaneously, increases urine output in hydrated and non-hydrated rats.
2. The diuretic action of postlobin-O is not due to the pressor hormone contaminating it.
3. Pitocin produces a diuretic effect in non-hydrated rats equal to that of postlobin-O.
4. Postlobin-O antagonizes the antidiuretic action of postlobin-V. Therefore, the rat antidiuretic assay method is only of value when the ratio between oxytocic and pressor activities of the standard preparation is similar to that of the unknown preparation.
Footnotes
- Received January 15, 1937.
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