Abstract
Two subjects showed marked lowering of general sensitiveness within one hour after the administration of acetphenetedin (5-15 grains) by mouth. The criterion was the threshold for electrocutaneous sensibility (Martin method).
One of the subjects, the one with greater normal sensitiveness, gave evidence of a certain degree of tolerance after ten doses, distributed over a period of two months. The other subject reacted markedly throughout the investigation, and was generally more affected by the larger doses than by the smaller ones.
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