Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

THE URIC ACID CONCENTRATION OF THE BLOOD AS INFLUENCED BY ATOPHAN AND RADIUM EMANATION

MORRIS S. FINE, ARTHUR F. CHACE and CAMERON VERNON BAILEY
Journal of Pharmacology and Experimental Therapeutics November 1914, 6 (2) 219-234;
MORRIS S. FINE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ARTHUR F. CHACE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CAMERON VERNON BAILEY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effect of the action of atophan upon the uric acid output in the urine and the decrease in the concentration of this substance in the blood begins to be manifest nearly as soon as absorption of the drug has taken place; and has exerted its maximum influence in about one day. With continued administration of atophan, the extra elimination of uric acid is practically over in two days, and further use of the drug in the doses employed (3 to 5 gms. daily) fails to induce a further reduction in the uric acid of the blood. When the administration of the drug is discontinued there is a marked fall in the output of uric acid and a rise in the concentration of this substance in the blood commensurate with the initial increase in the urine and decrease in the blood. The rise in the blood probably begins as soon as the use of atophan has been discontinued, attaining in most cases the original level in two days.

The influence of atophan is interpreted to indicate an increased permeability of the kidney for uric acid. The data is presumed to indicate a more or less quantitative relationship between the increased output in the urine and the decrease in the blood. Radium administered intravenously as the bromide and inhalation of emanation in strengths as high as 100 M. U. per liter, for long periods of time failed to disclose any influence upon the uric acid concentration of the blood.

Footnotes

    • Received July 6, 1914.

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 6, Issue 2
1 Nov 1914
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
THE URIC ACID CONCENTRATION OF THE BLOOD AS INFLUENCED BY ATOPHAN AND RADIUM EMANATION
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

THE URIC ACID CONCENTRATION OF THE BLOOD AS INFLUENCED BY ATOPHAN AND RADIUM EMANATION

MORRIS S. FINE, ARTHUR F. CHACE and CAMERON VERNON BAILEY
Journal of Pharmacology and Experimental Therapeutics November 1, 1914, 6 (2) 219-234;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

THE URIC ACID CONCENTRATION OF THE BLOOD AS INFLUENCED BY ATOPHAN AND RADIUM EMANATION

MORRIS S. FINE, ARTHUR F. CHACE and CAMERON VERNON BAILEY
Journal of Pharmacology and Experimental Therapeutics November 1, 1914, 6 (2) 219-234;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance
  • Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics