Abstract
The action of dicentrine on intact animals, blood pressure, perfused heart, uterine strips, decerebrate and decapitate animals has been studied. It was found that the action of this drug is similar to that of corydine. Small doses in frogs produce drowsiness and depression, while larger doses result in convulsions which cease on pithing the cord. In the perfused frog's heart dicentrine produces diminution in the amplitude and heart block. Uterine muscle is depressed. Blood pressure in rabbits is reduced and removal of the cerebral hemispheres has little or no effect on the convulsions in rabbits, while technical difficulties prevented conclusive results in decapitate animals.
Footnotes
- Received July 29, 1936.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.