Abstract
1. The duration of sensory anesthesia produced by the intraspinal injections of a series of six local anesthetics in the rabbit has been determined.
2. The duration of this effect appeared to be closely related to the concentration of the local anesthetic in the injected fluid.
3. Motor paralysis began, as a rule, before sensory anesthesia was discernible and lasted until after the sensory effects had disappeared.
4. The average durations of sensory anesthesia produced by the minimal anesthetic doses or concentrations of the six local anesthetics have been found to be: procaine HCl, 0.9 per cent, 16 minutes; tutocaine, 0.5 per cent, 11 minutes; panthesine, 0.5 per cent, 18 minutes; metycaine, 0.86 per cent, 13 minutes; pantocaine, 0.05 per cent, 25 minutes; and nupercaine, 0.07 per cent, 41 minutes.
Footnotes
- Received March 23, 1936.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
