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Research ArticleArticle

ON THE DURATION OF SPINAL ANESTHESIA IN THE RABBIT

RAYMOND N. BIETER, J. J. McNEARNEY, RAYMOND W. CUNNINGHAM and OA LENZ
Journal of Pharmacology and Experimental Therapeutics July 1936, 57 (3) 264-273;
RAYMOND N. BIETER
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J. J. McNEARNEY
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RAYMOND W. CUNNINGHAM
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OA LENZ
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Abstract

1. The duration of sensory anesthesia produced by the intraspinal injections of a series of six local anesthetics in the rabbit has been determined.

2. The duration of this effect appeared to be closely related to the concentration of the local anesthetic in the injected fluid.

3. Motor paralysis began, as a rule, before sensory anesthesia was discernible and lasted until after the sensory effects had disappeared.

4. The average durations of sensory anesthesia produced by the minimal anesthetic doses or concentrations of the six local anesthetics have been found to be: procaine HCl, 0.9 per cent, 16 minutes; tutocaine, 0.5 per cent, 11 minutes; panthesine, 0.5 per cent, 18 minutes; metycaine, 0.86 per cent, 13 minutes; pantocaine, 0.05 per cent, 25 minutes; and nupercaine, 0.07 per cent, 41 minutes.

Footnotes

    • Received March 23, 1936.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 57, Issue 3
1 Jul 1936
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Research ArticleArticle

ON THE DURATION OF SPINAL ANESTHESIA IN THE RABBIT

RAYMOND N. BIETER, J. J. McNEARNEY, RAYMOND W. CUNNINGHAM and OA LENZ
Journal of Pharmacology and Experimental Therapeutics July 1, 1936, 57 (3) 264-273;

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Research ArticleArticle

ON THE DURATION OF SPINAL ANESTHESIA IN THE RABBIT

RAYMOND N. BIETER, J. J. McNEARNEY, RAYMOND W. CUNNINGHAM and OA LENZ
Journal of Pharmacology and Experimental Therapeutics July 1, 1936, 57 (3) 264-273;
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