Abstract
1. Sixty aryl and unsymmetrical alkylaryl thioureas were synthesized for examination of hypnotic potency. Fifty-three were successfully tested in mice.
2. These thioureas uniformly had hypnotic potency, some of a high order.
3. The hypnotic effects of the thioureas improve with increase in molecular weight in homologous series. The maximum effect occurs when the alkyl substituents reach the propyl to amyl groups.
4. The aryl and lower unsymmetrical alkylaryl thioureas are consistently more potent than their urea analogs. The higher alkylaryl thioureas, however, closely resemble in potency the few analogous ureas thus far examined.
Footnotes
- Received February 6, 1936.
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