Abstract
Dendrobine, C16H25O2N, has a slight but demonstrable analgesic and antipyretic action—much weaker than that of amidopyrine. It produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure, suppresses the respiration, inhibits isolated rabbits' intestines, and contracts isolated guinea pigs' uteri.
The minimal lethal dose determined by intravenous injection in white mice and rats is 20 mgm. per kilogram, that in guinea pigs 22 mgm., and that in rabbits 17 mgm. per kilogram. Death is preceded by convulsions.
The convulsions caused by dendrobine appear to be central in origin—probably due to the stimulating action on both the medulla and the spinal cord. Sodium amytal has a detoxifying effect on dendrobine.
Footnotes
- Received August 11, 1935.
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