Abstract

The oxytocic substance of the posterior pituitary hormone produces no naked eye or microscopic changes in the livers of normal rabbits which are not found in the livers of control rabbits; whereas the fraction containing a marked excess of pressor activity and also melanophore activity causes fatty infiltration in varying degree. These changes are reflected in the amount of ethersoluble material extracted from the liver. The pressor fraction causes a very great increase, the oxytocic fraction much less. The pressor fraction therefore is probably mainly responsible for the changes observed by Coope and Chamberlain (1).