Abstract
1. Sodium amytal (Lilly) affords a safe and convenient method for the routine production of anesthesia in the rat.
2. There is a marked difference in the amount of the substance which can be safely employed in males and females. The female dosage is just one-half the male dosage. Immature rats require the lower dosage.
3. The efficiency of the drug is lessened by dilution. The more concentrated solutions produce more uniform results with the actual use of less amytal.
4. In the rat, the only contraindication to the use of sodium amytal so far found is a chronic respiratory infection.
5. Death in cases of overdosage is generally due to respiratory failure.
Footnotes
- Received January 25, 1932.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.