Abstract
Additional evidence is presented to show that the depressor activity of certain brain extracts is not due to histamine, choline or acetyl choline.
These brain extracts produce a depression of blood-pressure in rabbits while histamine produces an elevation,1 and they give a negative Pauly reaction indicating the absence of histamine. The brain extracts produce a fall of blood pressure in an atropinized animal while choline and acetyl choline produce no effect under similar conditions. Further evidence that its action is not due to acetyl choline is the observation that a solution of acetyl choline having a depressor activity equal to that of the brain extract loses practically all of its activity when the solution is made alkaline. If the activity of the crude brain extract were due to acetyl choline, the methods of purification employed would destroy most if not all of its depressor activity.
Footnotes
- Received June 4, 1930.
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