Abstract

The dialkylamino propandiol mono- and di-phenylurethan hydrochlorides are local anesthetics of merit. The di-isobutylamino propandiol mono-phenylurethan hydrochloride is over six times as strong as cocaine on the rabbit's cornea and over three times as strong as either novocaine or cocaine in an intradermal wheal. It is very decidedly less toxic than either of these drugs as attested by subcutaneous injection into white mice and, white rats. It is astingent, to which property the great duration of anesthesia may be attributed, and appears to produce no untoward effects either on the cornea or in the human skin. While it is not the least irritating member of the series, it is less destructive to the cornea than either cocaine or butyn in concentrations of equal activity and is unobjectionable when injected intradermally in a dilute solution. Its strength is approximately doubled upon sterilization. These properties apply to other members of the series, and are being further investigated.