Abstract
1. Pitressin in both acid and alkaline solutions produces vasoconstriction of the coronary vessels in excised perfused isolated hearts of rabbits (confirmatory of Anrep). Pitocin similarly injected caused coronary vaso-dilatation.
2. The peripheral vessels of frogs are always constricted by pitressin in alkaline solution, but usually dilated when the acid solution is used. This latter action, we believe, is due to the acidity of the fluid injected.
3. Aqueous extracts of pure pituitary powder causes an increase in the volume of the heart (confirmation of Kolls and Geiling, and Bodo).
4. Pitressin produces an increase in the volume of the dog's heart when injected intravenously.
5. A second injection of either pitressin or pituitary extract subsequent to the first injection did not influence cardiac volume.
6. In our experiments pitocin did not influence cardiac volume when injected intravenously.
Footnotes
- Received May 25, 1930.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
