Abstract
1. The interference of acriflavine against the trypanocidal action of triphenyl methane dyes observed by Browning and Schnitzer in animals, a phenomenon of "drug-fastness," can be duplicated in vitro upon the CO2 production of yeasts.
2. This reaction appears to be a phenomenon due to adsorption of the first dye upon the surface of the cell interfering with the adsorption of the second.
3. This analogy should furnish a means for studying further questions of drug-fastness and for further physico-chemical investigation of many questions in chemotherapy.
Footnotes
- Received February 27, 1930.
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