Journal of Pharmacology and Experimental Therapeutics: 388 (2)

February 01, 2024; Volume 388,Issue 2

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Conquering Metabolic Syndrome: Navigating Pharmacological Avenues for Comprehensive Therapeutics
Gracious R. Ross

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 229-231; DOI: https://doi.org/10.1124/jpet.123.001908
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A Synthetic ERR Agonist Alleviates Metabolic Syndrome
Cyrielle Billon, Emmalie Schoepke, Amer Avdagic, Arindam Chatterjee, Andrew A. Butler, Bahaa Elgendy, John K. Walker and Thomas P. Burris

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 232-240; DOI: https://doi.org/10.1124/jpet.123.001733

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Goofball Polypharmacy
Joseph F. Cotten

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 241-243; DOI: https://doi.org/10.1124/jpet.123.001930
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Ventilatory Effects of Fentanyl, Heroin, and d-Methamphetamine, Alone and in Mixtures in Male Rats Breathing Normal Air
Takato Hiranita, Nicholas P. Ho and Charles P. France

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 244-256; DOI: https://doi.org/10.1124/jpet.123.001653

Special Section on Medical Countermeasures

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Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats–Editorial
Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 257-259; DOI: https://doi.org/10.1124/jpet.123.002025
Open Access
Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents
Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 260-267; DOI: https://doi.org/10.1124/jpet.123.002040
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Strengthening Warfighter Resiliency Using Broad-Spectrum or Host-Directed Therapies within the Rapid Acquisition and Investigation of Drugs for Repurposing Program
Lauren Quattrochi, Anthony Cardile, Amanda Love, Andrew Glenn, Micah Almas, Alicia Coronado, Matthew Clark, Charles Paschal and Lucy Ward

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 268-272; DOI: https://doi.org/10.1124/jpet.123.001721
$Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic$

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Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic
Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 273-300; DOI: https://doi.org/10.1124/jpet.123.001816
Open Access
Evidence Implicating Blood-Brain Barrier Impairment in the Pathogenesis of Acquired Epilepsy following Acute Organophosphate Intoxication
Pedro N. Bernardino, Audrey S. Luo, Peter M. Andrew, Chelsea M. Unkel, Marco I. Gonzalez, Angie Gelli and Pamela J. Lein

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 301-312; DOI: https://doi.org/10.1124/jpet.123.001836
$Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage$

Open Access
Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage
Tanveer Singh, Sreevidhya Ramakrishnan, Xin Wu and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 313-324; DOI: https://doi.org/10.1124/jpet.123.001747
Open Access
Chronic Epilepsy and Mossy Fiber Sprouting Following Organophosphate-Induced Status Epilepticus in Rats
Robert E. Blair, Elisa Hawkins, Lauren R. Pinchbeck, Robert J. DeLorenzo and Laxmikant S. Deshpande

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 325-332; DOI: https://doi.org/10.1124/jpet.123.001739
Open Access
[¹¹C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat
Thomas R. Hayes, Chih-Kai Chao, Joseph E. Blecha, Tony L. Huynh, Henry F. VanBrocklin, Kurt R. Zinn, John M. Gerdes and Charles M. Thompson

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 333-346; DOI: https://doi.org/10.1124/jpet.123.001832
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Efficacy of Lacosamide and Rufinamide as Adjuncts to Midazolam-Ketamine Treatment Against Cholinergic-Induced Status Epilepticus in Rats
Lucille A. Lumley, Donna A. Nguyen, Marcio de Araujo Furtado, Jerome Niquet, Emily O. Linz, Caroline R. Schultz, Michael F. Stone and Claude G. Wasterlain

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 347-357; DOI: https://doi.org/10.1124/jpet.123.001789
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Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication
Li-Ping Liang, Jennifer N. Pearson-Smith, Brian J. Day and Manisha Patel

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 358-366; DOI: https://doi.org/10.1124/jpet.123.001708
Open Access
Sarin-Induced Neuroinflammation in Mouse Brain Is Attenuated by the Caspase Inhibitor Q-VD-OPh
Ekta J. Shah, William C. Grunwald, Teresa L. Garrett, Thomas L. Brown and David R. Cool

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 367-375; DOI: https://doi.org/10.1124/jpet.123.001820
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Evaluation of Midazolam-Ketamine-Allopregnanolone Combination Therapy against Cholinergic-Induced Status Epilepticus in Rats
Donna A. Nguyen, Michael F. Stone, Caroline R. Schultz, Marcio de Araujo Furtado, Jerome Niquet, Claude G. Wasterlain and Lucille A. Lumley

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 376-385; DOI: https://doi.org/10.1124/jpet.123.001784
Open Access
Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations, and Electrographic Ictal Biomarkers
Sreevidhya Ramakrishnan, Tanveer Singh and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 386-398; DOI: https://doi.org/10.1124/jpet.123.001817
Open Access
Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-Induced Long-Term Neurological Dysfunction, Neurodegeneration, and Neuroinflammation
Doodipala Samba Reddy, Tanveer Singh, Sreevidhya Ramakrishnan, Madeline Huber and Xin Wu

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 399-415; DOI: https://doi.org/10.1124/jpet.123.001819
$A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-Term Epileptic Seizure Activity, Neurologic Dysfunction and Neurodegeneration$

Open Access
A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-Term Epileptic Seizure Activity, Neurologic Dysfunction and Neurodegeneration
Tanveer Singh, Sreevidhya Ramakrishnan, Xin Wu and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 416-431; DOI: https://doi.org/10.1124/jpet.123.001794
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Preventing Long-Term Brain Damage by Nerve Agent–Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment
Marcio De Araujo Furtado, Vassiliki Aroniadou-Anderjaska, Taiza H. Figueiredo, Volodymyr I. Pidoplichko, James P. Apland, Katia Rossetti and Maria F.M. Braga

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 432-450; DOI: https://doi.org/10.1124/jpet.123.001710
Open Access
Long-Term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids
Michael James Neff and Doodipala Samba Reddy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 451-468; DOI: https://doi.org/10.1124/jpet.123.001763
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Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard–Induced Corneal Injuries in a Rabbit Model
Neha Mishra, Rama Kant, Kushal Kandhari, Neera Tewari-Singh, Poojya Anantharam, Claire R. Croutch, Mina B. Pantcheva, J. Mark Petrash, Houmam Araj, Chapla Agarwal and Rajesh Agarwal

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 469-483; DOI: https://doi.org/10.1124/jpet.123.001680
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Nitrogen Mustard-Induced Ex Vivo Human Cornea Injury Model and Therapeutic Intervention by Dexamethasone
Neha Mishra, Rama Kant, Kushal Kandhari, David A. Ammar, Neera Tewari-Singh, Mina B. Pantcheva, J. Mark Petrash, Chapla Agarwal and Rajesh Agarwal

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 484-494; DOI: https://doi.org/10.1124/jpet.123.001760
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Mitigation of Nitrogen Mustard–Induced Skin Injury by the β-Blocker Carvedilol and Its Enantiomers
Ayaz Shahid, Steven Yeung, Rita Miwalian, Angela Mercado, Bradley T. Andresen and Ying Huang

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 495-505; DOI: https://doi.org/10.1124/jpet.123.001663
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Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface
Jinhong Pan, Satyabrata Pany, Rafael Martinez-Carrasco and M. Elizabeth Fini

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 506-517; DOI: https://doi.org/10.1124/jpet.123.001697
Open Access
The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard–Induced Ocular Toxicity
Assylbek Zhylkibayev, Trong Thuan Ung, James Mobley, Mohammad Athar and Marina Gorbatyuk

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 518-525; DOI: https://doi.org/10.1124/jpet.123.001814
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Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach
Robert Shalwitz, Tovah Day, Anna Kotsakis Ruehlmann, Lindsay Julio, Shellaina Gordon, Adrianna Vandeuren, Marian Nelson, Megan Lyman, Kyle Kelly, Amber Altvater, Celinia Ondeck, Sean O’Brien, Tracey Hamilton, Ryan L. Hanson, Kayla Wayman, Alexandrea Miller, Isaiah Shalwitz, Eric Batchelor and Patrick McNutt

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 526-535; DOI: https://doi.org/10.1124/jpet.123.001686
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Dermal Exposure to Vesicating Nettle Agent Phosgene Oxime: Clinically Relevant Biomarkers and Skin Injury Progression in Murine Models
Dinesh G. Goswami, Satyendra K. Singh, Ebenezar O.M. Okoyeocha, Andrew K. Roney, Omid Madadgar, Rick Tuttle, William Sosna, Poojya Anantharam, Claire R. Croutch, Rajesh Agarwal and Neera Tewari-Singh

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 536-545; DOI: https://doi.org/10.1124/jpet.123.001718
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HSP90, a Common Therapeutic Target for Suppressing Skin Injury Caused by Exposure to Chemically Diverse Classes of Blistering Agents
Ritesh Kumar Srivastava, Suhail Muzaffar, Jasim Khan, David K. Crossman, Anupam Agarwal and Mohammad Athar

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 546-559; DOI: https://doi.org/10.1124/jpet.123.001795
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Countermeasures against Pulmonary Threat Agents
Jacqui Marzec and Srikanth Nadadur

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 560-567; DOI: https://doi.org/10.1124/jpet.123.001822
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A Murine Model of Vesicant-Induced Acute Lung Injury
Iram Zafar, Shajer Manzoor, Nithya Mariappan, Shama Ahmad, Mohammad Athar, Veena Antony and Aftab Ahmad

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 568-575; DOI: https://doi.org/10.1124/jpet.123.001780
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Mesna Improves Outcomes of Sulfur Mustard Inhalation Toxicity in an Acute Rat Model
Heidi J. Nick, Carly A. Johnson, Amber R. Stewart, Sarah E. Christeson, Leslie A. Bloomquist, Amanda S. Appel, Abigail B. Donkor, Livia A. Veress, Brian A. Logue, Preston E. Bratcher and Carl W. White

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 576-585; DOI: https://doi.org/10.1124/jpet.123.001683
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Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid
Jaclynn A. Meshanni, Jordan M. Lee, Kinal N. Vayas, Rachel Sun, Chenghui Jiang, Grace L. Guo, Andrew J. Gow, Jeffrey D. Laskin and Debra L. Laskin

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 586-595; DOI: https://doi.org/10.1124/jpet.123.001557
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A Potential Antidote for Both Azide and Cyanide Poisonings
Linda L. Pearce, Kimberly K. Garrett, Yookyung Bae, Kristin L. Frawley, Samantha Carpenter Totoni and Jim Peterson

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 596-604; DOI: https://doi.org/10.1124/jpet.123.001719
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Cutaneous Arsenical Exposure Induces Distinct Metabolic Transcriptional Alterations of Kidney Cells
Kyle H. Moore, Laurence M. Boitet, Darshan S. Chandrashekar, Amie M. Traylor, Stephanie K. Esman, Elise N. Erman, Ritesh K. Srivastava, Jasim Khan, Mohammad Athar, Anupam Agarwal and James F. George

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 605-612; DOI: https://doi.org/10.1124/jpet.123.001742
Open Access
Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent–Induced Cutaneous Injuries
Satyanarayana Achanta, Narendranath Reddy Chintagari, Shrilatha Balakrishna, Boyi Liu and Sven-Eric Jordt

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 613-623; DOI: https://doi.org/10.1124/jpet.123.001666
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Oxidant-Dependent Sensitizing, Protective, and Mitigative Effects in X-Ray–Irradiated Pulmonary Endothelial Cells
Linda L. Pearce, Xi Zheng, Daniel S. Wilen, Andrea A. Cronican, Kristin L. Frawley and Jim Peterson

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 624-636; DOI: https://doi.org/10.1124/jpet.123.001714
Open Access
Aminopyridines Restore Ventilation and Reverse Respiratory Acidosis at Late Stages of Botulism in Mice
William T. McClintic, Zachary D. Chandler, Lalitha M. Karchalla, Celinia A. Ondeck, Sean W. O’Brien, Charity J. Campbell, Alan R. Jacobson and Patrick M. McNutt

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 637-646; DOI: https://doi.org/10.1124/jpet.123.001773
Open Access
Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate–Based Rat Model of Gulf War Illness
Ana Ribeiro-Davis, Dalia Y. Al Saeedy, Fay M. Jahr, Elisa Hawkins, Joseph L. McClay and Laxmikant S. Deshpande

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 647-654; DOI: https://doi.org/10.1124/jpet.123.001824

Behavioral Pharmacology

Open Access
Assessing Dose- and Sex-Dependent Antinociceptive Effects of Cannabidiol and Amitriptyline, Alone and in Combination, and Exploring Mechanism of Action Involving Serotonin 1A Receptors
Robert C. Barnes, Satish Banjara, Melissa C. McHann, Sharilyn Almodovar, Angela N. Henderson-Redmond, Daniel J. Morgan, Isabel Castro-Piedras and Josée Guindon

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 655-669; DOI: https://doi.org/10.1124/jpet.123.001855

Cardiovascular

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The Melatonin Derivative ITH13001 Prevents Hypertension and Cardiovascular Alterations in Angiotensin II-Infused Mice
Marta Martínez-Casales, Raquel Hernanz, Zoe González-Carnicero, María T. Barrús, Angela Martín, Ana M. Briones, Patrycja Michalska, Rafael León, Estefano Pinilla, Ulf Simonsen and María J. Alonso

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 670-687; DOI: https://doi.org/10.1124/jpet.123.001586
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The β-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with K_A Values Distinct From Their Equilibrium Dissociation Constants as β₂-Adrenoceptor Antagonists: Evidence for Functional Affinity
Omar Hamed, Varuna Jayasinghe and Mark A. Giembycz

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 688-700; DOI: https://doi.org/10.1124/jpet.123.001920

Gastrointestinal, Hepatic, Pulmonary, and Renal

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The Peptide DHα-(4-pentenyl)-ANPQIR-NH₂ Exhibits Antifibrotic Activity in Multiple Pulmonary Fibrosis Models Induced by Particulate and Soluble Chemical Fibrogenic Agents
Jieru Li, Bochuan Deng, Jiao Zhang, Xiang Zhang, Lu Cheng, Guofeng Li, Ping Su, Xiaokang Miao, Wenle Yang, Junqiu Xie and Rui Wang

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 701-714; DOI: https://doi.org/10.1124/jpet.123.001849

Neuropharmacology

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Repeated Activation of Pyramidal Neurons in the Prefrontal Cortex Alters Microglial Phenotype in Male Mice
Justin L. Bollinger, Matthew J. Horchar and Eric S. Wohleb

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 715-723; DOI: https://doi.org/10.1124/jpet.123.001759

Toxicology

Open Access
Inhibiting Inducible Nitric Oxide Synthase with 1400W Reduces Soman (GD)-Induced Ferroptosis in Long-Term Epilepsy-Associated Neuropathology: Structural and Functional Magnetic Resonance Imaging Correlations with Neurobehavior and Brain Pathology
Marson Putra, Suraj S. Vasanthi, Nikhil S. Rao, Christina Meyer, Madison Van Otterloo, Lal Thangi, Daniel R. Thedens, Sridhar S. Kannurpatti and Thimmasettappa Thippeswamy

Journal of Pharmacology and Experimental Therapeutics February 2024, 388 (2) 724-738; DOI: https://doi.org/10.1124/jpet.123.001929

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Special Section on Medical Countermeasures

Behavioral Pharmacology

Cardiovascular

Gastrointestinal, Hepatic, Pulmonary, and Renal

Neuropharmacology

Toxicology

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