Table of Contents

Drug Discovery and Translational Medicine

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  Open Access

  Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23

  Boyd Steere, Catherine Beidler, Andrea Martin, Stu Bright, Kristy Kikly and Robert J. Benschop

  Journal of Pharmacology and Experimental Therapeutics November 2023, 387 (2) 180-187; DOI: https://doi.org/10.1124/jpet.122.001512
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  Open Access

  Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice

  Allyson Anding, Sofia Kinton, Kaitlyn Baranowski, Alexander Brezzani, Hilde De Busser, Michael R. Dufault, Patrick Finn, Kelly Keefe, Tanya Tetrault, Yi Li, Weiliang Qiu, Katrien Raes, Olivier Vitse, Mindy Zhang, Robin Ziegler, S. Pablo Sardi, Bridge Hunter and Kelly George

  Journal of Pharmacology and Experimental Therapeutics November 2023, 387 (2) 188-203; DOI: https://doi.org/10.1124/jpet.123.001593
• Open Access

  The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers

  Moti Rosenstock, Leo Tseng, Andrew Pierce, Elliot Offman, Chao-Yin Chen, R. Will Charlton, Maya Margalit and Hank Mansbach

  Journal of Pharmacology and Experimental Therapeutics November 2023, 387 (2) 204-213; DOI: https://doi.org/10.1124/jpet.123.001618
• Open Access

  STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema

  Vahe Bedian, Nikolaos Biris, Charles Omer, Jou-Ku Chung, James Fuller, Rafif Dagher, Sachin Chandran, Peter Harwin, Tomas Kiselak, Jonathan Violin, Andrew Nichols and Pradeep Bista

  Journal of Pharmacology and Experimental Therapeutics November 2023, 387 (2) 214-225; DOI: https://doi.org/10.1124/jpet.123.001740