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Research ArticleSpecial Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

A Mathematical Model to Investigate the Effects of Ceralasertib and Olaparib in Targeting the Cellular DNA Damage Response Pathway

Kira Pugh, Michael Davies and Gibin Powathil
Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 55-65; DOI: https://doi.org/10.1124/jpet.122.001558
Kira Pugh
Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, United Kingdom (K.P., G.P.) and Oncology R&D, AstraZeneca, Cambridge, United Kingdom (M.D.)
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Michael Davies
Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, United Kingdom (K.P., G.P.) and Oncology R&D, AstraZeneca, Cambridge, United Kingdom (M.D.)
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Gibin Powathil
Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, United Kingdom (K.P., G.P.) and Oncology R&D, AstraZeneca, Cambridge, United Kingdom (M.D.)
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Article Information

vol. 387 no. 1 55-65
DOI 
https://doi.org/10.1124/jpet.122.001558
PubMed 
37391224

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 15, 2022
  • Accepted May 25, 2023
  • Published online September 15, 2023.

Article Versions

  • Earlier version (June 30, 2023 - 06:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kira Pugh,
  2. Michael Davies, and
  3. Gibin Powathil
  1. Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, United Kingdom (K.P., G.P.) and Oncology R&D, AstraZeneca, Cambridge, United Kingdom (M.D.)
  1. Address correspondence to:
    Kira Pugh, Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, UK. E-mail: k.a.pugh{at}swansea.ac.uk; or Gibin Powathil, Department of Mathematics, Faculty of Science and Engineering, Swansea University, Swansea, UK. E-mail: g.g.powathil{at}swansea.ac.uk
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Journal of Pharmacology and Experimental Therapeutics: 387 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 387, Issue 1
1 Oct 2023
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Research ArticleSpecial Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

Modelling the Effects of DNA Damage Response Inhibitor Drugs

Kira Pugh, Michael Davies and Gibin Powathil
Journal of Pharmacology and Experimental Therapeutics October 1, 2023, 387 (1) 55-65; DOI: https://doi.org/10.1124/jpet.122.001558

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Research ArticleSpecial Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

Modelling the Effects of DNA Damage Response Inhibitor Drugs

Kira Pugh, Michael Davies and Gibin Powathil
Journal of Pharmacology and Experimental Therapeutics October 1, 2023, 387 (1) 55-65; DOI: https://doi.org/10.1124/jpet.122.001558
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