Abstract
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BP) are RNA binding proteins that play a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression. Recent evidence suggests that G3BPs can also regulate mRNA expression through interactions with RNA outside of SGs. G3BPs have been associated with a number of disease states, including cancer progression, invasion, metastasis, and viral infections, and may be useful as a cancer therapeutic target. This review summarizes the biology of G3BP including their structure, function, localization, role in cancer progression, virus replication, mRNA stability, and SG formation. We will also discuss the potential of G3BPs as a therapeutic target.
SIGNIFICANCE STATEMENT This review will discuss the molecular mechanism(s) and functional role(s) of Ras-GTPase-activating protein (SH3 domain)-binding proteins in the context of stress granule formation, interaction with viruses, stability of RNA, and tumorigenesis.
Footnotes
- Received December 6, 2022.
- Accepted July 11, 2023.
This work was supported in part by National Institutes of Health National Cancer Institute [Grant R01 CA221152], Weill Cornell Medicine Clinical and Translational Science Center Pilot Award [Grant 1 UL1 TR002384], Weill Cornell Medicine Prostate SPORE Developmental Research Award (to P.Z.), and US Department of Defense [Grant W81XWH-17-1-0176] (to C.M.).
The authors declare that they have no conflict of interest with any company that could benefit from the findings of this manuscript.
- Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
In this issue
Jump to section
- Article
- Abstract
- Introduction
- Structure and Function of G3BPs in Different Cellular Processes
- Expression and Subcellular Localization of G3BPs
- Regulation of G3BPs at Transcriptional, Translational, and Posttranslational Levels
- Roles of G3BPs in Stress Granule Formation
- Contribution of G3BPs in Cancer
- Contributions of G3BPs in Other Diseases
- Roles of G3BPs in Viral Infection
- G3BPs as Potential Therapeutic Targets
- Concluding Remarks and Further Perspectives
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters