Journal of Pharmacology and Experimental Therapeutics: 387 (1)

October 01, 2023; Volume 387,Issue 1

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Partners in Pain: New Insights into The Role of CGRP Signaling in Cross-Organ Sensitization
Matthew D. Coates and Margaret A. Vizzard

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 1-3; DOI: https://doi.org/10.1124/jpet.123.001770
Open Access
Antinociceptive Effects of an Anti-CGRP Antibody in Rat Models of Colon-Bladder Cross-Organ Sensitization
Ehsan Noor-Mohammadi, Casey O. Ligon, Kimberly D. Mackenzie, Jennifer Stratton, Sara J. Shnider and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001480

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Fixing a Broken Heart Opens the Door to Developing K_ATP Channel Agonists as Pain Relievers
Vanessa O. Zambelli and Eric R. Gross

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 15-17; DOI: https://doi.org/10.1124/jpet.123.001716
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K_ATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine-Induced Hypersensitivity, and Precipitated Withdrawal in Mice
Alexis Doucette, Kayla Johnson, Shelby Hulke, Sunna Mujteba, Elena Miller, Belle Meyer, Peter I. Dosa and Amanda H. Klein

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 18-26; DOI: https://doi.org/10.1124/jpet.122.001522

Special Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

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Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine–Editorial
Annabelle Ballesta and James M. Gallo

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 27-30; DOI: https://doi.org/10.1124/jpet.123.001842
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Optimizing IFN Alpha Therapy against Myeloproliferative Neoplasms
Gurvan Hermange, Paul-Henry Cournède and Isabelle Plo

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 31-43; DOI: https://doi.org/10.1124/jpet.122.001561
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Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation
David Hodson, Hitesh Mistry, James Yates, Paul Farrington, Anna Staniszewska, Sofia Guzzetti, Michael Davies, Leon Aarons and Kayode Ogungbenro

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 44-54; DOI: https://doi.org/10.1124/jpet.122.001572
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A Mathematical Model to Investigate the Effects of Ceralasertib and Olaparib in Targeting the Cellular DNA Damage Response Pathway
Kira Pugh, Michael Davies and Gibin Powathil

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 55-65; DOI: https://doi.org/10.1124/jpet.122.001558
Open Access
Agent-Based Modelling Reveals the Role of the Tumor Microenvironment on the Short-Term Success of Combination Temozolomide/Immune Checkpoint Blockade to Treat Glioblastoma
Anudeep Surendran, Adrianne L. Jenner, Elham Karimi, Benoit Fiset, Daniela F. Quail, Logan A. Walsh and Morgan Craig

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 66-77; DOI: https://doi.org/10.1124/jpet.122.001571
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Mechanistically Weighted Metric to Predict In Vivo Antibody-Receptor Occupancy: An Analytical Approach
Eshita Khera, Jaeyeon Kim, Andrew Stein, Matt Ratanapanichkich and Greg M. Thurber

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 78-91; DOI: https://doi.org/10.1124/jpet.122.001540
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Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?
Marcus John Tindall, Lourdes Cucurull-Sanchez, Hitesh Mistry and James W.T. Yates

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 92-99; DOI: https://doi.org/10.1124/jpet.122.001551

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Role(s) of G3BPs in Human Pathogenesis
Chandrani Mukhopadhyay and Pengbo Zhou

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 100-110; DOI: https://doi.org/10.1124/jpet.122.001538

Cellular and Molecular

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Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2–Mediated Protection against Alcohol-Induced Apoptosis
Nikhil Y. Patil, Iulia Rus and Aditya D. Joshi

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 111-120; DOI: https://doi.org/10.1124/jpet.123.001670

Drug Discovery and Translational Medicine

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Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates
Anna Dari, Laura Solforosi, Ramon Roozendaal, Richard M.W. Hoetelmans, Juan-José Pérez-Ruixo and Muriel Boulton

Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 121-130; DOI: https://doi.org/10.1124/jpet.123.001591

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Special Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

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