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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2023; Volume 387,Issue 1

Viewpoint

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    Partners in Pain: New Insights into The Role of CGRP Signaling in Cross-Organ Sensitization
    Matthew D. Coates and Margaret A. Vizzard
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 1-3; DOI: https://doi.org/10.1124/jpet.123.001770
  • Open Access
    Antinociceptive Effects of an Anti-CGRP Antibody in Rat Models of Colon-Bladder Cross-Organ Sensitization
    Ehsan Noor-Mohammadi, Casey O. Ligon, Kimberly D. Mackenzie, Jennifer Stratton, Sara J. Shnider and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001480

Viewpoint

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    Fixing a Broken Heart Opens the Door to Developing KATP Channel Agonists as Pain Relievers
    Vanessa O. Zambelli and Eric R. Gross
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 15-17; DOI: https://doi.org/10.1124/jpet.123.001716
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    KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine-Induced Hypersensitivity, and Precipitated Withdrawal in Mice
    Alexis Doucette, Kayla Johnson, Shelby Hulke, Sunna Mujteba, Elena Miller, Belle Meyer, Peter I. Dosa and Amanda H. Klein
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 18-26; DOI: https://doi.org/10.1124/jpet.122.001522

Special Section on Quantitative Systems Pharmacology: A Foundation to Establish Precision Medicine

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    Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine–Editorial
    Annabelle Ballesta and James M. Gallo
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 27-30; DOI: https://doi.org/10.1124/jpet.123.001842
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    Optimizing IFN Alpha Therapy against Myeloproliferative Neoplasms
    Gurvan Hermange, Paul-Henry Cournède and Isabelle Plo
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 31-43; DOI: https://doi.org/10.1124/jpet.122.001561
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    Radiation in Combination with Immune Checkpoint Blockade and DNA Damage Response Inhibitors in Mice: Dosage Optimization in MC38 Syngeneic Tumors via Modelling and Simulation
    David Hodson, Hitesh Mistry, James Yates, Paul Farrington, Anna Staniszewska, Sofia Guzzetti, Michael Davies, Leon Aarons and Kayode Ogungbenro
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 44-54; DOI: https://doi.org/10.1124/jpet.122.001572
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    A Mathematical Model to Investigate the Effects of Ceralasertib and Olaparib in Targeting the Cellular DNA Damage Response Pathway
    Kira Pugh, Michael Davies and Gibin Powathil
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 55-65; DOI: https://doi.org/10.1124/jpet.122.001558
  • Open Access
    Agent-Based Modelling Reveals the Role of the Tumor Microenvironment on the Short-Term Success of Combination Temozolomide/Immune Checkpoint Blockade to Treat Glioblastoma
    Anudeep Surendran, Adrianne L. Jenner, Elham Karimi, Benoit Fiset, Daniela F. Quail, Logan A. Walsh and Morgan Craig
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 66-77; DOI: https://doi.org/10.1124/jpet.122.001571
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    Mechanistically Weighted Metric to Predict In Vivo Antibody-Receptor Occupancy: An Analytical Approach
    Eshita Khera, Jaeyeon Kim, Andrew Stein, Matt Ratanapanichkich and Greg M. Thurber
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 78-91; DOI: https://doi.org/10.1124/jpet.122.001540
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    Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?
    Marcus John Tindall, Lourdes Cucurull-Sanchez, Hitesh Mistry and James W.T. Yates
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 92-99; DOI: https://doi.org/10.1124/jpet.122.001551

Minireview

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    Role(s) of G3BPs in Human Pathogenesis
    Chandrani Mukhopadhyay and Pengbo Zhou
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 100-110; DOI: https://doi.org/10.1124/jpet.122.001538

Cellular and Molecular

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    Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2–Mediated Protection against Alcohol-Induced Apoptosis
    Nikhil Y. Patil, Iulia Rus and Aditya D. Joshi
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 111-120; DOI: https://doi.org/10.1124/jpet.123.001670

Drug Discovery and Translational Medicine

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    Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates
    Anna Dari, Laura Solforosi, Ramon Roozendaal, Richard M.W. Hoetelmans, Juan-José Pérez-Ruixo and Muriel Boulton
    Journal of Pharmacology and Experimental Therapeutics October 2023, 387 (1) 121-130; DOI: https://doi.org/10.1124/jpet.123.001591
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 387 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 387, Issue 1
1 Oct 2023
  • Table of Contents
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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