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Index by author

July 01, 2023; Volume 386,Issue 1

A

  1. Alley, Jennifer

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Amin, Rupesh P.

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  3. Andreyeva, Tatyana A

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  4. Arichika, Naoya

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

B

  1. Badger, Calen

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  2. Bennett, Donald

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  3. Berstein, Gabriel

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  4. Blaustein, Robert O.

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  5. Bretschneider, Tom

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  6. Brilisauer, Klaus

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  7. Brugarolas, Pedro

    1. Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [18F]3-Fluoro-4-Aminopyridine and Identification of Its Metabolites
      Yang Sun, Karla M. Ramos-Torres and Pedro Brugarolas
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 93-101; DOI: https://doi.org/10.1124/jpet.122.001462

C

  1. Cadieux, Jay A

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  2. Chahal, Navjot

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  3. Chen, Hongxing

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  4. Chowdhury, Sultan

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  5. Cohen, Charles J.

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  6. Collinge, Mark

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  7. Corson, Timothy W.

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

  8. Crouse, Kimberly K

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  9. Curran, Geoffry L.

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  10. Cutts, Alison

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

D

  1. DiMaggio, Giovanni

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Donovan, Carol B

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

E

  1. Ebbini, Malik

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  2. Eyers, Maryanne

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

F

  1. Fish, Susan C

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Frisbie, Richard K

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  3. Fryer, Ryan M.

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  4. Fuchs, Bryan C.

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

G

  1. Garren, Jeonifer

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Garrick, Michael D.

    1. Managing Iron Overload: A Gut Check
      Michael D. Garrick
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 1-3; DOI: https://doi.org/10.1124/jpet.123.001645

  3. Goldberg, Y. Paul

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  4. Grimwood, Michael

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

H

  1. Hartman, Gabriella D.

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

  2. Haruta, Junpei

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

  3. Hasegawa, Yoshitaka

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  4. Hayden, Michael

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  5. Hegen, Martin

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  6. Himmel, Herbert

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  7. Hirata, Takashi

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  8. Hiyama, Hidetaka

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

  9. Hsiao, Peng

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

I

  1. Ibanez, Gerardo

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  2. Imredy, John P.

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  3. Inatani, Shoko

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

J

  1. Johnson, Timothy

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  2. Jones, Amanda K.

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

K

  1. Kandimalla, Karunya K.

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  2. Kelley, Mark R.

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

  3. Kojima, Naoki

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  4. Koretsune, Hiroko

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  5. Koyama, Noriyuki

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

  6. Kumpf, Steven W

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

L

  1. Lagrutta, Armando

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  2. Lanz, Thomas A

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  3. Li, Wei

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  4. Lin, Sophia

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  5. Lowe, Val J.

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

M

  1. Mansour, Tarek

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  2. McHugh, Mark

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  3. Mijit, Mahmut

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

  4. Min, Paul H.

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  5. Muniyandi, Anbukkarasi

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

N

  1. Namdari, Rostam

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  2. Newman, Leah

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  3. Ng, Khing Jow

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

O

  1. Ohara, Hiroki

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  2. Okada, Minoru

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

  3. Oziolor, Elias

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

P

  1. Papazyan, Romeo

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  2. Pimstone, Simon

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  3. Prescott, Judith

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

Q

  1. Qian, Hu Sheng

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  2. Qian, Jesse

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

R

  1. Ramirez, Jocelyn

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  2. Ramos-Torres, Karla M.

    1. Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [18F]3-Fluoro-4-Aminopyridine and Identification of Its Metabolites
      Yang Sun, Karla M. Ramos-Torres and Pedro Brugarolas
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 93-101; DOI: https://doi.org/10.1124/jpet.122.001462

  3. Ratkay, Laszlo G

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  4. Reed, Lori A

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  5. Rives, Marie-Laure

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  6. Robinette, Lee

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

S

  1. Schnute, Mark E

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Shih, Amy Y.

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  3. Siegel, Ronald A.

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  4. Sojo, Luis

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  5. Song, Yang

    1. Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Open Access
      Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease
      Anbukkarasi Muniyandi, Gabriella D. Hartman, Yang Song, Mahmut Mijit, Mark R. Kelley and Timothy W. Corson
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 15-25; DOI: https://doi.org/10.1124/jpet.122.001563

  6. Stalewski, Jacek

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  7. Stevens, Erin

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  8. Steyn, Stefan J

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  9. Sun, Yang

    1. Metabolic Stability of the Demyelination Positron Emission Tomography Tracer [18F]3-Fluoro-4-Aminopyridine and Identification of Its Metabolites
      Yang Sun, Karla M. Ramos-Torres and Pedro Brugarolas
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 93-101; DOI: https://doi.org/10.1124/jpet.122.001462

T

  1. Tahara, Tomonori

    1. Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
      Hidetaka Hiyama, Naoya Arichika, Minoru Okada, Noriyuki Koyama, Tomonori Tahara and Junpei Haruta
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609

  2. Takahashi, Teisuke

    1. Renoprotective Effect of TP0472993, a Novel and Selective 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor, in Mouse Models of Renal Fibrosis
      Takashi Hirata, Hiroki Ohara, Naoki Kojima, Hiroko Koretsune, Yoshitaka Hasegawa, Shoko Inatani and Teisuke Takahashi
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 56-69; DOI: https://doi.org/10.1124/jpet.122.001521

  3. Thorarensen, Atli

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  4. Thorn, Mitchell

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  5. Tietjen, Ian

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

U

  1. Ueki, Akemi

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

V

  1. Vargas, Amanda P

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  2. Villalona, Jorge

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  3. Vincent, Fabien

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  4. Vincent, Michael S

    1. Open Access
      A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
      Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jesse Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefan J Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent and Gabriel Berstein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 80-92; DOI: https://doi.org/10.1124/jpet.122.001452

  5. Vinzing, Maya

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

  6. Vömel, Matthias

    1. Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Open Access
      Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat
      Herbert Himmel, Armando Lagrutta, Matthias Vömel, Rupesh P. Amin, John P. Imredy, Timothy Johnson, Maya Vinzing, Judith Prescott and Robert O. Blaustein
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 26-34; DOI: https://doi.org/10.1124/jpet.122.001368

W

  1. Waldbrook, Matthew

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  2. Wang, Lushan

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  3. Wang, Zengtao

    1. Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging
      Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L. Curran, Paul H. Min, Ronald A. Siegel, Val J. Lowe and Karunya K. Kandimalla
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 102-110; DOI: https://doi.org/10.1124/jpet.122.001545

  4. Webb, Michael

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  5. Wilks, James

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  6. Wu, Shije

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

X

  1. Xie, Zhiwei

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

Y

  1. Yin, Jun

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

  2. Young, Clint

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435

  3. Yue, Yong

    1. Open Access
      pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential
      Jacek Stalewski, Amy Y. Shih, Romeo Papazyan, Jocelyn Ramirez, Gerardo Ibanez, Peng Hsiao, Yong Yue, Jun Yin, Calen Badger, Shije Wu, Akemi Ueki, Bryan C. Fuchs and Marie-Laure Rives
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 35-44; DOI: https://doi.org/10.1124/jpet.122.001554

Z

  1. Zeveleva, Svetlana

    1. Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Open Access
      Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model
      Amanda K. Jones, Hongxing Chen, Khing Jow Ng, Jorge Villalona, Mark McHugh, Svetlana Zeveleva, James Wilks, Klaus Brilisauer, Tom Bretschneider, Hu Sheng Qian and Ryan M. Fryer
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 70-79; DOI: https://doi.org/10.1124/jpet.122.001532

  2. Zhang, Zaihui

    1. Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
      Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen
      Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435
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