Journal of Pharmacology and Experimental Therapeutics: 386 (1)

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About the cover: Compound 13 potency is significantly reduced by GPR4 mutations to conserved orthosteric site comprising H269. See the article by Stalewski et al. (dx.doi.org/10.1124/jpet.122.001554).

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

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