Journal of Pharmacology and Experimental Therapeutics: 385 (3)

June 01, 2023; Volume 385,Issue 3

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Bath Salts to Therapies: Can Separation of Adverse and Therapeutic Effects of Substituted Cathinones Lead to a Medication for Psychostimulant Use Disorder?
Ellen M. Unterwald and Scott M. Rawls

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 159-161; DOI: https://doi.org/10.1124/jpet.123.001650
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Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats
Michael R. Chojnacki, Eric B. Thorndike, John S. Partilla, Kenner C. Rice, Charles W. Schindler and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 162-170; DOI: https://doi.org/10.1124/jpet.122.001478

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Assessment of Abuse-Related Discriminative Stimulus Effects of Nicotine Aerosol in Rodents
Yasmin Alkhlaif and Keith L. Shelton

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 171-179; DOI: https://doi.org/10.1124/jpet.122.001520
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Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma and Takato Hiranita

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 180-192; DOI: https://doi.org/10.1124/jpet.122.001525

Open Access
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy
Takashi Ishikawa, Hiroe Hara, Ayumi Kawano, Kimio Tohyama, Yuichi Kajita, Yuhei Miyanohana, Tatsuki Koike and Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 193-204; DOI: https://doi.org/10.1124/jpet.122.001449
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In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide
Daniel J. Blackwell, Abigail N. Smith, Tri Do, Aaron Gochman, Jeffrey Schmeckpeper, Corey R. Hopkins, Wendell S. Akers, Jeffrey N. Johnston and Bjorn C. Knollmann

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 205-213; DOI: https://doi.org/10.1124/jpet.122.001455

Open Access
BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies
Leo Thomas, Sarah Low, Gale Hansen, Remko A. Bakker and Nina Zippel

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 214-221; DOI: https://doi.org/10.1124/jpet.122.001473

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Correction to “Cannabinoid Tolerance in S426A/S430A x β-Arrestin 2 Knockout Double-Mutant Mice”
Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 222; DOI: https://doi.org/10.1124/jpet.122.001367err