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Research ArticleDrug Discovery and Translational Medicine
Open Access

Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition

Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele
Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 331-342; DOI: https://doi.org/10.1124/jpet.122.001255
Irmgard Hofmann
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Anke Baum
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Marco H. Hofmann
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Francesca Trapani
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Claudia Reichel-Voda
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Diane Ehrensperger
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Martin Aichinger
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Florian Ebner
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Nicole Budano
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Norbert Schweifer
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Martina Sykora
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Erik Depla
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Joachim Boucneau
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Andreas Gschwind
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Norbert Kraut
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Frank Hilberg
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Klaus-Peter Künkele
Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
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Article Information

vol. 384 no. 3 331-342
DOI 
https://doi.org/10.1124/jpet.122.001255
PubMed 
36241203

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 5, 2022
  • Accepted August 31, 2022
  • Published online February 23, 2023.

Article Versions

  • Earlier version (October 14, 2022 - 03:10).
  • Earlier version (February 21, 2023 - 05:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2023 by The Author(s) This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Irmgard Hofmann,
  2. Anke Baum,
  3. Marco H. Hofmann,
  4. Francesca Trapani,
  5. Claudia Reichel-Voda,
  6. Diane Ehrensperger,
  7. Martin Aichinger,
  8. Florian Ebner,
  9. Nicole Budano,
  10. Norbert Schweifer,
  11. Martina Sykora1,
  12. Erik Depla2,
  13. Joachim Boucneau3,
  14. Andreas Gschwind,
  15. Norbert Kraut,
  16. Frank Hilberg, and
  17. Klaus-Peter Künkele4
  1. Cancer Immunology and Immune Modulation (I.H., C.R.-V., M.S.), Cancer Pharmacology and Disease Positioning (A.B., M.H.H., M.A., F.E., F.H.), Cancer Research (D.E., A.G., N.K., K.-P.K.), and Oncology Translational Sciences (F.T., N.B., N.S.), Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; and Ablynx NV, Ghent/Zwijnaarde, Belgium (E.D., J.B.)
  1. Address correspondence to:
    Irmgard Hofmann, Cancer Immunology and Immune Modulation, Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, 1121 Vienna, Austria. E-mail: irmgard.hofmann{at}boehringer-ingelheim.com
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Journal of Pharmacology and Experimental Therapeutics: 384 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 3
1 Mar 2023
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Research ArticleDrug Discovery and Translational Medicine

VEGF/ANG2 Inhibition Alone or Combined with PD-1 Inhibition

Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele
Journal of Pharmacology and Experimental Therapeutics March 1, 2023, 384 (3) 331-342; DOI: https://doi.org/10.1124/jpet.122.001255

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Research ArticleDrug Discovery and Translational Medicine

VEGF/ANG2 Inhibition Alone or Combined with PD-1 Inhibition

Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele
Journal of Pharmacology and Experimental Therapeutics March 1, 2023, 384 (3) 331-342; DOI: https://doi.org/10.1124/jpet.122.001255
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