Journal of Pharmacology and Experimental Therapeutics: 384 (3)

March 01, 2023; Volume 384,Issue 3

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Paving the Way for Cancer Therapy a Nano Step at a Time
Divya Venkatesh and Taha Merghoub

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 327-330; DOI: https://doi.org/10.1124/jpet.122.001514
Open Access
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition
Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 331-342; DOI: https://doi.org/10.1124/jpet.122.001255

Behavioral Pharmacology

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Delta Opioid Receptor-Mediated Antidepressant-Like Effects of Diprenorphine in Mice
Keith M. Olson, Todd M. Hillhouse, Gwendolyn E. Burgess, Joshua L. West, James E. Hallahan, Isaac J. Dripps, Allison G. Ladetto, Kenner C. Rice, Emily M. Jutkiewicz and John R. Traynor

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 343-352; DOI: https://doi.org/10.1124/jpet.122.001182
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3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder
Michelle R. Doyle, Lindsey N. Peng, Jianjing Cao, Kenner C. Rice, Amy Hauck Newman and Gregory T. Collins

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 353-362; DOI: https://doi.org/10.1124/jpet.122.001419
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Attenuation of the Positive-Reinforcing Effects of Ultra-Potent Fentanyl Analogs, Along with Those of Fentanyl and Heroin, During Daily Treatment with Methocinnamox in Rhesus Monkeys
Lisa R. Gerak and Charles P. France

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 363-371; DOI: https://doi.org/10.1124/jpet.122.001267
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The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys
Omeed Rahimi, Jianjing Cao, Jenny Lam, Steven R. Childers, Rana Rais, Linda J. Porrino, Amy Hauck Newman and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 372-381; DOI: https://doi.org/10.1124/jpet.122.001363

Cardiovascular

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Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Na_v1.5 to Antiarrhythmic Drugs
Yang Zheng and Isabelle Deschênes

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 417-428; DOI: https://doi.org/10.1124/jpet.122.001407

Chemotherapy, Antibiotics, and Gene Therapy

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Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase
John S. Lazo, Kelly N. Isbell, Sai Ashish Vasa, Danielle C. Llaneza, Ettore J. Rastelli, Peter Wipf and Elizabeth R. Sharlow

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 429-438; DOI: https://doi.org/10.1124/jpet.122.001401
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Ocular Administration of Palonosetron in the Prevention of Cisplatin-Induced Nausea and Vomiting
Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Häkkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle and Heikki Joensuu

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 439-444; DOI: https://doi.org/10.1124/jpet.122.001444

Drug Discovery and Translational Medicine

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The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease
Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark C. McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina Gueneva-Boucheva, Jehrod B. Brenneman, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M. Boustany-Kari and Steven S. Pullen

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 382-392; DOI: https://doi.org/10.1124/jpet.122.001423
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Identification of Glucose Transport Modulators In Vitro and Method for Their Deep Learning Neural Network Behavioral Evaluation in Glucose Transporter 1–Deficient Mice
Gauri Kathote, Qian Ma, Gustavo Angulo, Hong Chen, Vikram Jakkamsetti, Aksharkumar Dobariya, Levi B. Good, Bruce Posner, Jason Y. Park and Juan M. Pascual

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 393-405; DOI: https://doi.org/10.1124/jpet.122.001428
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The Effects of Dual GLP-1/Glucagon Receptor Agonists with Different Receptor Selectivity in Mouse Models of Obesity and Nonalcoholic Steatohepatitis
Ashref Kayed, Simone Anna Melander, Suheb Khan, Kim Vietz Andreassen, Morten Asser Karsdal and Kim Henriksen

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 406-416; DOI: https://doi.org/10.1124/jpet.122.001440

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Neutralizing MIP3α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats
Ubong S. Ekperikpe, Bibek Poudel, Corbin A. Shields, Sautan Mandal, Denise C. Cornelius and Jan M. Williams

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 445-454; DOI: https://doi.org/10.1124/jpet.122.001298

Inflammation, Immunopharmacology, and Asthma

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Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome
Artur Świerczek and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 455-472; DOI: https://doi.org/10.1124/jpet.122.001477

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Table of Contents

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Behavioral Pharmacology

Cardiovascular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

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