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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2023; Volume 384,Issue 2

Viewpoint

  • You have access
    In Vitro Trials: The Dawn of a New Era for Drug Discovery in Atopic Dermatitis?
    R Giacomelli and MC Fargnoli
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 245-247; DOI: https://doi.org/10.1124/jpet.122.001469
  • Human Induced Pluripotent Stem Cell–Derived Keratinocyte-Like Cells for Research on Protease-Activated Receptor 2 in Nonhistaminergic Cascades of Atopic Dermatitis 
    You have access
    Human Induced Pluripotent Stem Cell–Derived Keratinocyte-Like Cells for Research on Protease-Activated Receptor 2 in Nonhistaminergic Cascades of Atopic Dermatitis 
    Rio Nishimoto, Chinatsu Kodama, Hiromi Yamashita and Fumiyuki Hattori
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 248-253; DOI: https://doi.org/10.1124/jpet.122.001412

Cellular and Molecular

  • Open Access
    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
    Wei Xue, Jie Hao, Qiuping Zhang, Ronghua Jin, Zhuo Luo, Xin Yang, Yanying Liu, Qinpei Lu, Yiqiang Ouyang and Hongwei Guo
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 254-264; DOI: https://doi.org/10.1124/jpet.122.001189

Chemotherapy, Antibiotics, and Gene Therapy

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    Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide
    Jessika Carvajal-Moreno, Victor A. Hernandez, Xinyi Wang, Junan Li, Jack C. Yalowich and Terry S. Elton
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 265-276; DOI: https://doi.org/10.1124/jpet.122.001429

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    HM15912, a Novel Long-Acting Glucagon-Like Peptide-2 Analog, Improves Intestinal Growth and Absorption Capacity in a Male Rat Model of Short Bowel Syndrome
    Jaehyuk Choi, Jinbong Lee, Eunjin Park, Hyunjoo Kwon, Daejin Kim, Sungmin Bae, In Young Choi and Ha Hyung Kim
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 277-286; DOI: https://doi.org/10.1124/jpet.122.001381
  • You have access
    Role of Hydrogen Sulfide in the Development of Colonic Hypomotility in a Diabetic Mouse Model Induced by Streptozocin
    Xiaojing Quan, Jie Zhang, Yanli Liu, Ceng Sun, Hesheng Luo and Jinhai Wang
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 287-295; DOI: https://doi.org/10.1124/jpet.122.001392

Metabolism, Transport, and Pharmacogenetics

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    The Effects of Indobufen on Micro-Inflammation and Peritoneal Transport Function in Patients Undergoing Continuous Ambulate Peritoneal Dialysis: A Prospective Randomized Controlled Study
    Fang Liu, Hao Zhang, Hong Wu, Shikun Yang, Jun Liu and Jianwen Wang
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 296-305; DOI: https://doi.org/10.1124/jpet.122.001138

Neuropharmacology

  • Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice
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    Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice
    Sarah E. Davis, Mark J. Ferris, Subramaniam Ananthan, Corinne E. Augelli-Szafran and Jun Zhu
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 306-314; DOI: https://doi.org/10.1124/jpet.122.001291
  • Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures
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    Attenuation of Epileptogenesis and Cognitive Deficits by a Selective and Potent Kv7 Channel Opener in Rodent Models of Seizures
    Xiao-fei Zhuang, Yu-xue Liu, Zhi-hong Yang, Qin Gao, Lei Wang, Chuanxia Ju and KeWei Wang
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 315-325; DOI: https://doi.org/10.1124/jpet.122.001328

Erratum

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    Correction to “Interactive Effects of µ-Opioid and Adrenergic-α2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine”
    Journal of Pharmacology and Experimental Therapeutics February 2023, 384 (2) 326; DOI: https://doi.org/10.1124/jpet.122.001192err
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 2
1 Feb 2023
  • Table of Contents
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  • Viewpoint
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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