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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2023; Volume 384,Issue 1

Viewpoint

  • You have access
    Istaroxime and Beyond: New Therapeutic Strategies to Specifically Activate SERCA and Treat Heart Failure
    Roberta Avvisato, Stanislovas S. Jankauskas and Gaetano Santulli
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 227-230; DOI: https://doi.org/10.1124/jpet.122.001446
  • Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function
    Open Access
    Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function
    Martina Arici, Mara Ferrandi, Paolo Barassi, Shih-Che Hsu, Eleonora Torre, Andrea Luraghi, Carlotta Ronchi, Gwo-Jyh Chang, Francesco Peri, Patrizia Ferrari, Giuseppe Bianchi, Marcella Rocchetti and Antonio Zaza
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 231-244; DOI: https://doi.org/10.1124/jpet.122.001335

Special Section on Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools

  • You have access
    Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools
    Gaetano Santulli
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 225-226; DOI: https://doi.org/10.1124/jpet.122.001457
  • You have access
    The Multiplicity of Argonaute Complexes in Mammalian Cells
    Maurizio Mauro, Massimiliano Berretta, Giuseppe Palermo, Vincenzo Cavalieri and Gaspare La Rocca
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 1-9; DOI: https://doi.org/10.1124/jpet.122.001158
  • You have access
    The Role of Non-Coding RNAs in Chromosomal Instability in Cancer
    Swati Mohapatra, Melanie Winkle, Anh N. Ton, Dien Nguyen and George A. Calin
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 10-19; DOI: https://doi.org/10.1124/jpet.122.001357
  • You have access
    Regulation of Ferroptosis by Non-Coding RNAs: Mechanistic Insights
    Ammad Ahmad Farooqi, Gulnara Kapanova, Sundetgali Kalmakhanov, Abay Z. Kussainov and Zaure Datkhayeva
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 20-27; DOI: https://doi.org/10.1124/jpet.121.001225
  • You have access
    Interplay between Non-Coding RNAs and NRF2 in Different Cancers: Spotlight on MicroRNAs and Long Non-Coding RNAs
    İlhan Yaylım, Ammad Ahmad Farooqi, Pelin Telkoparan-Akillilar and Luciano Saso
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 28-34; DOI: https://doi.org/10.1124/jpet.121.000921
  • You have access
    Circulating microRNAs as Reliable Tumor Biomarkers: Opportunities and Challenges Facing Clinical Application
    Sherien M. El-Daly, Shaimaa A. Gouhar and Zakaria Y. Abd Elmageed
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 35-51; DOI: https://doi.org/10.1124/jpet.121.000896
  • You have access
    The Functions and Mechanisms of Translatable Circular RNAs
    Chang Liu, Xinying Wu, Priyanka Gokulnath, Guoping Li and Junjie Xiao
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 52-60; DOI: https://doi.org/10.1124/jpet.122.001085
  • Open Access
    CircRNA_33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway
    Kai Ai, Lei Yi, Yinhuai Wang and Yuan Li
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 61-71; DOI: https://doi.org/10.1124/jpet.122.001280
  • You have access
    Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease
    Jessica Gambardella, Antonella Fiordelisi, Daniela Sorriento, Federica Cerasuolo, Antonietta Buonaiuto, Roberta Avvisato, Antonio Pisani, Fahimeh Varzideh, Eleonora Riccio, Gaetano Santulli and Guido Iaccarino
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 72-78; DOI: https://doi.org/10.1124/jpet.122.001250
  • You have access
    Long Non-Coding RNAs as Cellular Metabolism and Haematopoiesis Regulators
    Anjali Sangeeth, Mahesh Malleswarapu, Amit Mishra and Ravi Kumar Gutti
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 79-91; DOI: https://doi.org/10.1124/jpet.121.001120
  • You have access
    Role of Long Non-Coding RNAs in Human-Induced Pluripotent Stem Cells Derived Megakaryocytes: A p53, HOX Antisense Intergenic RNA Myeloid 1, and miR-125b Interaction Study
    Swati Dahariya, Sanjeev Raghuwanshi, Vasanth Thamodaran, Shaji R. Velayudhan and Ravi Kumar Gutti
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 92-101; DOI: https://doi.org/10.1124/jpet.121.001095
  • You have access
    Cardiovascular Implications of microRNAs in Coronavirus Disease 2019
    Carmine Izzo, Valeria Visco, Jessica Gambardella, Germano Junior Ferruzzi, Antonella Rispoli, Maria Rosaria Rusciano, Anna Laura Toni, Nicola Virtuoso, Albino Carrizzo, Paola Di Pietro, Guido Iaccarino, Carmine Vecchione and Michele Ciccarelli
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 102-108; DOI: https://doi.org/10.1124/jpet.122.001210
  • You have access
    Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19
    Jessica Gambardella, Urna Kansakar, Celestino Sardu, Vincenzo Messina, Stanislovas S. Jankauskas, Raffaele Marfella, Paolo Maggi, Xujun Wang, Pasquale Mone, Giuseppe Paolisso, Daniela Sorriento and Gaetano Santulli
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 109-115; DOI: https://doi.org/10.1124/jpet.122.001209
  • You have access
    Empagliflozin Improves the MicroRNA Signature of Endothelial Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Diabetes
    Pasquale Mone, Angela Lombardi, Urna Kansakar, Fahimeh Varzideh, Stanislovas S. Jankauskas, Antonella Pansini, Stefania Marzocco, Stefano De Gennaro, Michele Famiglietti, Gaetano Macina, Salvatore Frullone and Gaetano Santulli
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 116-122; DOI: https://doi.org/10.1124/jpet.121.001251
  • Open Access
    The Role of microRNA in the Development, Diagnosis, and Treatment of Cardiovascular Disease: Recent Developments
    Anetta Wronska
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 123-132; DOI: https://doi.org/10.1124/jpet.121.001152
  • RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
    Open Access
    RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
    Gavin M. Traber and Ai-Ming Yu
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 133-154; DOI: https://doi.org/10.1124/jpet.122.001234

Behavioral Pharmacology

  • You have access
    Effects of 2,5-Dimethoxy-4-Methylamphetamine (DOM) and 2-Piperazin-1-yl-Quinoline (Quipazine) on Fentanyl Versus Food Choice in Rhesus Monkeys
    David R. Maguire
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 155-162; DOI: https://doi.org/10.1124/jpet.122.001318

Drug Discovery and Translational Medicine

  • Open Access
    Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma
    Floriane Lignet, Christina Esdar, Gina Walter-Bausch, Manja Friese-Hamim, Sofia Stinchi, Elise Drouin, Samer El Bawab, Andreas D. Becker, Claude Gimmi, Michael P. Sanderson and Felix Rohdich
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 163-172; DOI: https://doi.org/10.1124/jpet.122.001355

Metabolism, Transport, and Pharmacogenetics

  • Open Access
    Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors 
    Terry Podoll, Paul G. Pearson, Allard Kaptein, Jerry Evarts, Gerjan de Bruin, Maaike Emmelot-van Hoek, Anouk de Jong, Bart van Lith, Hao Sun, Stephen Byard, Adrian Fretland, Niels Hoogenboom, Tjeerd Barf and J. Greg Slatter
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 173-186; DOI: https://doi.org/10.1124/jpet.122.001116

Neuropharmacology

  • You have access
    Depression of Synaptic N-methyl-D-Aspartate Responses by Xenon and Nitrous Oxide
    Naoki Kotani, Il-Sung Jang, Michiko Nakamura, Kiku Nonaka, Hideaki Nagami and Norio Akaike
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 187-196; DOI: https://doi.org/10.1124/jpet.122.001346
  • Open Access
    Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood–Brain Barrier of Mice
    Akihiko Goto, Syunsuke Yamamoto, Tomoko Igari, Shin-ichi Matsumoto, Ikumi Chisaki, Koichi Iida, Miyu Nakayama, Akira Oda, Yuuichi Kakoi, Akio Uchida, Kenichi Miyata, Makiya Nishikawa, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota and Hideki Hirabayashi
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 197-204; DOI: https://doi.org/10.1124/jpet.122.001331
  • You have access
    Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation
    Daniel V. Quaranta, Riley R. Weaver, Kristen K. Baumann, Takashi Fujimoto, Lindsey M. Williams, Hyung Chan Kim, Aric F. Logsdon, Mohamed Omer, May J. Reed, William A. Banks and Michelle A. Erickson
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 205-223; DOI: https://doi.org/10.1124/jpet.122.001380

Erratum

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    Correction to “Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice”
    Journal of Pharmacology and Experimental Therapeutics January 2023, 384 (1) 204; DOI: https://doi.org/10.1124/jpet.121.001055err
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Journal of Pharmacology and Experimental Therapeutics: 384 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 1
1 Jan 2023
  • Table of Contents
  • Table of Contents (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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