Journal of Pharmacology and Experimental Therapeutics: 383 (3)

December 01, 2022; Volume 383,Issue 3

Behavioral Pharmacology

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Interactive Effects of µ-Opioid and Adrenergic-α₂ Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine
Samuel Obeng, Francisco Leon, Avi Patel, Julio D. Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F. Restrepo, Lea R. Gamez-Jimenez, Nicholas P. Ho, Maria P. Guerrero Calvache, Victoria L.C. Pallares, Justin A. Helmes, Sakura K. Shiomitsu, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson and Takato Hiranita

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 182-198; DOI: https://doi.org/10.1124/jpet.122.001192
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Self-Administration of Fentanyl-Alprazolam Combinations by Rhesus Monkeys Responding under a Progressive-Ratio Schedule
Lais F. Berro, C. Austin Zamarripa and James K. Rowlett

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 199-207; DOI: https://doi.org/10.1124/jpet.122.001191

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Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats
Hasan Alhaddad, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Edward Melenski, Richard L. Bell and Youssef Sari

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 208-216; DOI: https://doi.org/10.1124/jpet.122.001147
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A Physiologically-Based Pharmacokinetic Model of the Brain Considering Regional Lipid Variance
Andrew McPherson Heitman, Robert R. Bies and Sorell L. Schwartz

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 217-226; DOI: https://doi.org/10.1124/jpet.122.001256
Open Access
Botulinum Toxin A, a Better Choice for Skeletal Muscle Block in a Comparative Study With Lidocaine in Rats
Ke Xu, Zhan Zhang, Yueying Li, Lili Song, Jin Gou, Chengkuan Sun, Jiayang Li, Shuang Du, Rangjuan Cao and Shusen Cui

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 227-237; DOI: https://doi.org/10.1124/jpet.122.001313
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Competitive Interactions Between Propofol and Diazepam: Studies in GABA_A Receptors and Zebrafish
Andrea Pence, Helen Hoyt, Megan McGrath, Stuart A. Forman and Douglas E. Raines

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 238-245; DOI: https://doi.org/10.1124/jpet.122.001337

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Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
Eva M del Amo, Arto Urtti and Veli-Pekka Ranta

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 246-247; DOI: https://doi.org/10.1124/jpet.122.001257

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Response to Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”
Mitalee Tamhane, Kenneth T. Luu and Mayssa Attar

Journal of Pharmacology and Experimental Therapeutics December 2022, 383 (3) 248-249; DOI: https://doi.org/10.1124/jpet.122.001439